"[E]very five hours you spend awake is roughly equivalent to one standard alcoholic beverage in terms of how your brain will perform." #readingToday
In many ways, a sleep-deprived brain acts like a brain under the influence of alcohol. In a hand-eye coordination task, each hour you are awake sets you back as much as an extra 0.004 percent alcohol concentration in your blood. This means every five hours you spend awake is roughly equivalent to one standard alcoholic beverage in terms of how your brain will perform. After 20 hours awake your performance is as impaired as if you had exceeded the legal limit in the United States (0.08 percent blood alcohol). Research into the impacts of sleep deprivation on the brain is responsible for the rapidly increasing number of sleep-related warning signs on our motorways. Happily, however, sleep deprivation's negative impact on vigilance and attention can be completely counteracted by caffeine—coffee addicts rejoice!—so a good coping strategy is simply to have a double espresso and wait 20 minutes for it to take effect before you get back on the road.
(Moon+ Reader Pro v2.3.3, The Secret World of Sleep: The Surprising Science of the Mind at Rest (MacSci))